Developmental and Oncogenic Signaling
DEVELOPMENTAL SIGNALLING OF THE GENITOURINARY SYSTEM
Coordinator: Dr. Mario Encinas
- Mouse modelling of the molecular mechanisms involved in the development of the genitourinary system.
- Study of the molecular mechanisms and biological effects of Sprouty in tissue modelling and development.
- Study of the functions of cellular senescence during development.
SIGNALLING OF NERVOUS SYSTEM DEVELOPMENT
Coordinator: Dr. Joaquim Egea
- Mouse modelling of the molecular mechanisms involved in brain development.
- Study of RhoGTPases and FLRT proteins in the development of the cerebral cortex.
- Molecular mechanisms of neuronal migration and axon guidance in the developing cortex and their contribution to related diseases.
ONCOGENIC SIGNALLING
Coordinator: Dr. Xavier Dolcet
- Generation of mouse models of endometrial carcinogenesis.
- Identification of targeted therapies for endometrial cancer.
- Study of molecular alterations following PTEN deficiency in endometrial, colorectal and prostate cancers.
- Analysis of miRNA alterations in endometrial, colorectal and prostate cancer.
- Study of molecular-histopathological correlations in mouse models of endometrial cancer.
