Directory
Manuel Portero Otin

Manuel Portero Otin

Degree: PhD

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Groups

Publications

  • Herrero, A; Portero-Otin, M; Bellmunt, MJ; Pamplona, R; Barja, G

    Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage.

    MECHANISMS OF AGEING AND DEVELOPMENT 122 427-443. .

    [doi:10.1016/S0047-6374(01)00214-7]

  • Pamplona, R; Portero-Otin, M; Riba, D; Requena, JR; Thorpe, SR; Lopez-Torres, M; Barja, G

    Low fatty acid unsaturation: a mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans.

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 55 286-291. .

  • Portero-Otin, M; Pamplona, R; Bellmunt, MJ; Ruiz, C; Lafarga, A; Salvayre, R; Negre-Salvayre, A

    Maillard-reaction derived oxoaldehydes inhibit epidermal-growth factor receptor activity in human cultured endothelial cells

    Diabetes 49 1395-1395. .

  • Pamplona, R; Portero-Otin, M; Ruiz, C; Gredilla, R; Herrero, A; Barja, G

    Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals.

    MECHANISMS OF AGEING AND DEVELOPMENT 112 169-183. .

    [doi:10.1016/S0047-6374(99)00045-7]

  • Portero-Otin, M; Pamplona, R; Ruiz, MC; Cabiscol, E; Prat, J; Bellmunt, MJ

    Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney.

    Diabetes 48 2215-2220. .

    [doi:10.2337/diabetes.48.11.2215]

  • Pamplona, R; Portero-Otin, M; Ruiz, C; Bellmunt, MJ; Requena, JR; Thorpe, SR; Baynes, JW; Romero, M; Lopez-Torres, M; Barja, G

    Thyroid status modulates glycoxidative and lipoxidative modification of tissue proteins.

    FREE RADICAL BIOLOGY AND MEDICINE 27 901-910. .

    [doi:10.1016/S0891-5849(99)00135-5]

  • Portero-Otin, M

    Report of a 1998 EaSD-Bayer Travel Fellowship for Yound Scientists - Effect of oxidized LDL and glucose in tyrosine kinase receptors

    Diabetologia 42 37-38. .

  • Pamplona, R; Portero-Otin, M; Riba, D; Ledo, F; Gredilla, R; Herrero, A; Barja, G

    Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse.

    Zeitschrift Fur Gerontologie Und Geriatrie 32 883-883. .

  • Pamplona, R; Portero-Otin, M; Riba, D; Ledo, F; Gredilla, R; Herrero, A; Barja, G

    Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse.

    Aging-Clinical And Experimental Research 11 44-49. .

  • Pamplona, R; Portero-Otin, M; Requena, JR; Thorpe, SR; Herrero, A; Barja, G

    A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat.

    MECHANISMS OF AGEING AND DEVELOPMENT 106 283-296. .

    [doi:10.1016/S0047-6374(98)00121-3]

  • Guerrero, A; Pamplona, R; Portero-Otin, M; Barja, G; Lopez-Torres, M

    Effect of thyroid status on lipid composition and peroxidation in the mouse liver.

    FREE RADICAL BIOLOGY AND MEDICINE 26 73-80. .

    [doi:10.1016/S0891-5849(98)00173-7]

  • Pamplona, R; Portero-Otin, M; Riba, D; Ruiz, C; Prat, J; Bellmunt, MJ; Barja, G

    Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals.

    Journal Of Lipid Research 39 1989-1994. .

Projects

  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID
  • Metabolismo lipidico intracelular, procesamiento de ARNm y estrés celular en la encrucijada de la fisiopatología de la esclerosis lateral amiotrófica
  • Identification of compounds for inhibition of ACE2 membrane expression
  • Determinació de components bioactius derivats de la microbiota mitjançant micromostreig
  • Reposicionamiento terapéutico dirigido a inhibición de expresión de ACE2 y de proteolisis de trímero S viral
  • Estrés celulares y alteraciones en los lipidomas neuronales, gliales y extracelulares en la fisiopatología de la esclerosis lateral amiotrófica.
  • "Imagenoma de l'Envelliment": Estudi observacional poblacional per definir biomarcadors d'imatge RM corporal integral i òmics que s'associen al procés d'envelliment i a factors de risc biopsicosocial en subjectes adults i que defineixen la seva trajectòria vital cap a un envelliment saludable o bé la fragilitat i discapacitat.
  • Gut microbiota profile after consumption of a patented fiber formulation
  • ESTRES CELULAR Y DESLOCALIZACION DE FACTORES TRANSCRIPCIONALES EN LA FISIOPATOLOGIA DE LA ELA