Directory
Manuel Portero Otin

Manuel Portero Otin

Degree: PhD

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Groups

Publications

  • Herrero, A; Portero-Otin, M; Bellmunt, MJ; Pamplona, R; Barja, G

    Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage.

    MECHANISMS OF AGEING AND DEVELOPMENT 122 427-443. .

    [doi:10.1016/S0047-6374(01)00214-7]

  • Pamplona, R; Portero-Otin, M; Riba, D; Requena, JR; Thorpe, SR; Lopez-Torres, M; Barja, G

    Low fatty acid unsaturation: a mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans.

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 55 286-291. .

    [doi:10.1093/gerona/55.6.B286]

  • Portero-Otin, M; Pamplona, R; Bellmunt, MJ; Ruiz, C; Lafarga, A; Salvayre, R; Negre-Salvayre, A

    Maillard-reaction derived oxoaldehydes inhibit epidermal-growth factor receptor activity in human cultured endothelial cells

    DIABETES 49 1395-1395. .

  • Pamplona, R; Portero-Otin, M; Ruiz, C; Gredilla, R; Herrero, A; Barja, G

    Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals.

    MECHANISMS OF AGEING AND DEVELOPMENT 112 169-183. .

    [doi:10.1016/S0047-6374(99)00045-7]

  • Portero-Otin, M; Pamplona, R; Ruiz, MC; Cabiscol, E; Prat, J; Bellmunt, MJ

    Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney.

    DIABETES 48 2215-2220. .

    [doi:10.2337/diabetes.48.11.2215]

  • Pamplona, R; Portero-Otin, M; Ruiz, C; Bellmunt, MJ; Requena, JR; Thorpe, SR; Baynes, JW; Romero, M; Lopez-Torres, M; Barja, G

    Thyroid status modulates glycoxidative and lipoxidative modification of tissue proteins.

    FREE RADICAL BIOLOGY AND MEDICINE 27 901-910. .

    [doi:10.1016/S0891-5849(99)00135-5]

  • Portero-Otin, M

    Report of a 1998 EaSD-Bayer Travel Fellowship for Yound Scientists - Effect of oxidized LDL and glucose in tyrosine kinase receptors

    DIABETOLOGIA 42 37-38. .

  • Pamplona, R; Portero-Otin, M; Riba, D; Ledo, F; Gredilla, R; Herrero, A; Barja, G

    Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse.

    Zeitschrift Fur Gerontologie Und Geriatrie 32 883-883. .

  • Pamplona, R; Portero-Otin, M; Riba, D; Ledo, F; Gredilla, R; Herrero, A; Barja, G

    Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse.

    AGING-CLINICAL AND EXPERIMENTAL RESEARCH 11 44-49. .

    [doi:10.1007/BF03399636]

  • Pamplona, R; Portero-Otin, M; Requena, JR; Thorpe, SR; Herrero, A; Barja, G

    A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat.

    MECHANISMS OF AGEING AND DEVELOPMENT 106 283-296. .

    [doi:10.1016/S0047-6374(98)00121-3]

  • Guerrero, A; Pamplona, R; Portero-Otin, M; Barja, G; Lopez-Torres, M

    Effect of thyroid status on lipid composition and peroxidation in the mouse liver.

    FREE RADICAL BIOLOGY AND MEDICINE 26 73-80. .

    [doi:10.1016/S0891-5849(98)00173-7]

  • Pamplona, R; Portero-Otin, M; Riba, D; Ruiz, C; Prat, J; Bellmunt, MJ; Barja, G

    Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals.

    JOURNAL OF LIPID RESEARCH 39 1989-1994. .

Projects

  • Spanish Minor Stroke Perfusion Initiative: SMS-P Initiative
  • Contractació de personal investigador predoctoral en formació (FI SDUR 2024)
  • Ajuts Joan Oró per a la contractació de personal investigador predoctoral en formació FI 2025
  • SEED-ALS: Synergizing Efforts to Develop and Accelerate Breakthroughs in ALS Research
  • Natural microbicides from rice against current and emerging infectious diseases
  • Personal predoctoral en formació UdL 2025
  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • Targeting cryptic exons as biomarkers and ALS therapy
  • Comprehensive Roadmap and Preclinical Evaluation of Antisense Oligonucleotides (ASOs) Regulatory Development and Toxicological Assessment for ALS Treatment
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID