Directory
Manuel Portero Otin

Manuel Portero Otin

Degree: PhD

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Groups

Publications

  • Portero-Otin, M; Bellmunt, MJ; Requena, JR; Pamplona, R

    Protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids.

    Biochemical Society Transactions 31 1403-1405. .

    [doi:10.1042/]

  • Echtay, KS; Esteves, TC; Pakay, JL; Jekabsons, MB; Lambert, AJ; Portero-Otin, M; Pamplona, R; Vidal-Puig, AJ; Wang, S; Roebuck, SJ; Brand, MD

    A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling.

    Embo Journal 22 4103-4110. .

    [doi:10.1093/emboj/cdg412]

  • Ruiz, MC; Portero-Otin, M; Pamplona, R; Requena, JR; Prat, J; Lafarga, MA; Borras, M; Bellmunt, MJ

    Chemical and immunological characterization of oxidative nonenzymatic protein modifications in dialysis fluids.

    Peritoneal Dialysis International 23 23-32. .

  • Brand, MD; Pamplona, R; Portero-Otin, M; Requena, JR; Roebuck, SJ; Buckingham, JA; Clapham, JC; Cadenas, S

    Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3.

    BIOCHEMICAL JOURNAL 368 597-603. .

    [doi:10.1042/BJ20021077]

  • Pamplona, R; Portero-Otin, M; Requena, J; Gredilla, R; Barja, G

    Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls.

    MECHANISMS OF AGEING AND DEVELOPMENT 123 1437-1446. .

    [doi:10.1016/S0047-6374(02)00076-3]

  • Portero-Otin, M; Pamplona, R; Bellmunt, MJ; Ruiz, MC; Prat, J; Salvayre, R; Negre-Salvayre, A

    Advanced glycation end product precursors impair epidermal growth factor receptor signaling.

    Diabetes 51 1535-1542. .

    [doi:10.2337/diabetes.51.5.1535]

  • Pamplona R; Barja G; PORTERO OTIN, MANUEL

    Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation?

    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 959 475-490. .

  • Doñate T; Herreros A; Martinez E; Martinez J; Andrés E; Cabezas A; Ortiz A; de Prado A; Pou JM; Pamplona R; Portero Otin M; Bellmunt MJ

    Protein oxidative stress in dialysis patients.

    Advances In Peritoneal Dialysis. Conference On Peritoneal Dialysis 18 15-17. .

  • Pamplona, R; Portero-Otin, M; Bellmunt, MJ; Gredilla, R; Barja, G

    Aging increases N(epsilon)-(carboxymethyl)lysine and caloric restriction decreases N(epsilon)-(carboxyethyl)lysine and N(epsilon)-(malondialdehyde)lysine in rat heart mitochondrial proteins

    FREE RADICAL RESEARCH 36 47-54. .

    [doi:10.1080/10715760290001281]

  • Pamplona R; PORTERO OTIN, MANUEL; Bellmun MJ; Gredilla R; Barja G

    Aging increases Nepsilon-(carboxymethyl)lysine and caloric restriction decreases Nepsilon-(carboxyethyl)lysine and Nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins.

    FREE RADICAL RESEARCH 36 47-54. .

  • Portero-Otin, M; Bellmunt, MJ; Ruiz, MC; Barja, G; Pamplona, R

    Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential.

    Lipids 36 491-498. .

    [doi:10.1007/s11745-001-0748-y]

  • Gredilla, R; Lopez Torres, M; Portero-Otin, M; Pamplona, R; Barja, G

    Influence of hyper- and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle.

    MOL CELL BIOCHEM 221 41-48. .

    [doi:10.1023/A:1010930110382]

Projects

  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID
  • Metabolismo lipidico intracelular, procesamiento de ARNm y estrés celular en la encrucijada de la fisiopatología de la esclerosis lateral amiotrófica
  • Identification of compounds for inhibition of ACE2 membrane expression
  • Determinació de components bioactius derivats de la microbiota mitjançant micromostreig
  • Reposicionamiento terapéutico dirigido a inhibición de expresión de ACE2 y de proteolisis de trímero S viral
  • Estrés celulares y alteraciones en los lipidomas neuronales, gliales y extracelulares en la fisiopatología de la esclerosis lateral amiotrófica.
  • "Imagenoma de l'Envelliment": Estudi observacional poblacional per definir biomarcadors d'imatge RM corporal integral i òmics que s'associen al procés d'envelliment i a factors de risc biopsicosocial en subjectes adults i que defineixen la seva trajectòria vital cap a un envelliment saludable o bé la fragilitat i discapacitat.
  • Gut microbiota profile after consumption of a patented fiber formulation
  • ESTRES CELULAR Y DESLOCALIZACION DE FACTORES TRANSCRIPCIONALES EN LA FISIOPATOLOGIA DE LA ELA