Directory
Manuel Portero Otin

Manuel Portero Otin

Degree: PhD

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Groups

Publications

  • Pamplona, Reinald; Portero-Otin, Manuel; Sanz, Alberto; Ayala, Victoria; Vasileva, Ekaterina; Barja, Gustavo

    Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate.

    AGE 27 267-280. .

    [doi:10.1007/s11357-005-4562-x]

  • Ruiz, MC; Ayala, V; Portero-Otin, M; Requena, JR; Barja, G; Pamplona, R

    Protein methionine content and MDA-lysine adducts are inversely related to maximum life span in the heart of mammals.

    MECHANISMS OF AGEING AND DEVELOPMENT 126 1106-1114. .

    [doi:10.1016/j.mad.2005.04.005]

  • Dalfo, E; Portero-Otin, M; Ayala, V; Martinez, A; Pamplona, R; Ferrer, I

    Evidence of oxidative stress in the neocortex in incidental Lewy body disease.

    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 64 816-830. .

  • Dalfo, E.; Portero-Otin, M.; Ayala, V.; Pamplona, R.; Ferrer, I.

    Evidence of oxidative stress in the neocortex in incidental Lewy body disease

    MOLECULAR & CELLULAR PROTEOMICS 4 183-183. .

  • Pamplona, R; Dalfo, E; Ayala, VR; Bellmunt, MJ; Prat, J; Ferrer, I; Portero-Otin, M

    Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets.

    Journal Of Biological Chemistry 280 21522-21530. .

    [doi:10.1074/jbc.M502255200]

  • Sanz, A; Gredilla, R; Pamplona, R; Portero-Otin, M; Vara, E; Tresguerres, J; Barja, G

    Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals.

    Biogerontology 6 15-26. .

    [doi:10.1007/s10522-004-7380-0]

  • Miwa, S; Pamplona, R; Portero-Otin, M; Magwere, T; Jacobson, J; Lambert, A; Partridge, L; Brand, M

    Rapid and complete reversal of the effect of dietary restriction on protein oxidative damage in Drosophila

    FREE RADICAL BIOLOGY AND MEDICINE 39 126-127. .

  • Portero-Otin, M; Requena, JR; Bellmunt, MJ; Ayala, V; Pamplona, R

    Protein nonenzymatic modifications and proteasome activity in skeletal muscle from the short-lived rat and long-lived pigeon.

    Experimental Gerontology 39 1527-1535. .

    [doi:10.1016/j.exger.2004.08.001]

  • Pamplona, R; Portero-Otin, M

    Advanced glycation end products in urine: are some sugar-derived products better than others?

    Journal Of Laboratory And Clinical Medicine 144 58-59. .

    [doi:10.1016/j.lab.2004.04.007]

  • Lambert, AJ; Portero-Otin, M; Pamplona, R; Merry, BJ

    Effect of ageing and caloric restriction on specific markers of protein oxidative damage and membrane peroxidizability in rat liver mitochondria.

    MECHANISMS OF AGEING AND DEVELOPMENT 125 529-538. .

    [doi:10.1016/j.mad.2004.06.002]

  • Venditti, P; De Rosa, R; Portero-Otin, M; Pamplona, R; Di Meo, S

    Cold-induced hyperthyroidism produces oxidative damage in rat tissues and increases susceptibility to oxidants.

    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 36 1319-1331. .

    [doi:10.1016/j.biocel.2003.11.005]

  • Pamplona, R; Portero-Otin, M; Sanz, A; Requena, J; Barja, G

    Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain.

    Experimental Gerontology 39 725-733. .

    [doi:10.1016/j.exger.2004.01.006]

Projects

  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID
  • Metabolismo lipidico intracelular, procesamiento de ARNm y estrés celular en la encrucijada de la fisiopatología de la esclerosis lateral amiotrófica
  • Identification of compounds for inhibition of ACE2 membrane expression
  • Determinació de components bioactius derivats de la microbiota mitjançant micromostreig
  • Reposicionamiento terapéutico dirigido a inhibición de expresión de ACE2 y de proteolisis de trímero S viral
  • Estrés celulares y alteraciones en los lipidomas neuronales, gliales y extracelulares en la fisiopatología de la esclerosis lateral amiotrófica.
  • "Imagenoma de l'Envelliment": Estudi observacional poblacional per definir biomarcadors d'imatge RM corporal integral i òmics que s'associen al procés d'envelliment i a factors de risc biopsicosocial en subjectes adults i que defineixen la seva trajectòria vital cap a un envelliment saludable o bé la fragilitat i discapacitat.
  • Gut microbiota profile after consumption of a patented fiber formulation
  • ESTRES CELULAR Y DESLOCALIZACION DE FACTORES TRANSCRIPCIONALES EN LA FISIOPATOLOGIA DE LA ELA