Directori de persones
Josep Enric Esquerda Colell

Josep Enric Esquerda Colell

Grau: Doctor/a

973 702 427
josep.esquerda(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/A-7377-2010

Grups

Publicacions

  • Hernández S; Casanovas A; Piedrafita L; Tarabal O; Esquerda JE

    Neurotoxic species of misfolded SOD1G93A recognized by antibodies against the P2X4 subunit of the ATP receptor accumulate in damaged neurons of transgenic animal models of amyotrophic lateral sclerosis.

    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 69 176-187. .

    [doi:10.1097/NEN.0b013e3181cd3e33]

  • Brunet, Nuria; Tarabal, Olga; Esquerda, Josep E.; Caldero, Jordi

    Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.

    Journal Of Comparative Neurology 516 277-290. .

    [doi:10.1002/cne.22118]

  • Caldero, Jordi; Brunet, Nuria; Ciutat, Dolors; Hereu, Marta; Esquerda, Josep E.

    Development of microglia in the chick embryo spinal cord: implications in the regulation of motoneuronal survival and death.

    Journal Of Neuroscience Research 87 2447-2466. .

    [doi:10.1002/jnr.22084]

  • Barbier, Sandrine; Chatre, Laurent; Bras, Marlene; Sancho, Patricia; Roue, Gael; Virely, Clemence; Yuste, Victor J.; Baudet, Sylvie; Rubio, Manuel; Esquerda, Josep E.; Sarfati, Marika; Merle-Beral, Helene; Susin, Santos A.

    Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton.

    HAEMATOLOGICA 94 507-517. .

    [doi:10.3324/haematol.13690]

  • Ribas, Judit; Yuste, Victor J.; Garrofe-Ochoa, Xenia; Meijer, Laurent; Esquerda, Josep E.; Boix, Jacint

    7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death.

    BIOCHEMICAL PHARMACOLOGY 76 39-52. .

    [doi:10.1016/j.bcp.2008.03.023]

  • Oppenheim, Ronald W.; Caldero, Jordi; Cuitat, Doloros; Esquerda, Josep; McArdle, Joseph J.; Olivera, Baldornero M.; Prevette, David; Teichert, Russell W.

    The rescue of developing avian motoneurons from programmed cell death by a selective inhibitor of the fetal muscle-specific nicotinic acetylcholine receptor.

    Developmental Neurobiology 68 972-980. .

    [doi:10.1002/dneu.20636]

  • Casanovas, Anna; Hernandez, Sara; Tarabal, Olga; Rossello, Jaume; Esquerda, Josep E.

    Strong P2X4 purinergic receptor-like immunoreactivity is selectively associated with degenerating neurons in transgenic rodent models of amyotrophic lateral sclerosis.

    Journal Of Comparative Neurology 506 75-92. .

    [doi:10.1002/cne.21527]

  • Bras, Marlene; Yuste, Victor J.; Roue, Gael; Barbier, Sandrine; Sancho, Patricia; Virely, Clemence; Rubio, Manuel; Baudet, Sylvie; Esquerda, Josep E.; Merle-Beral, Helene; Sarfati, Marika; Susin, Santos A.

    Drp1 mediates caspase-independent type III cell death in normal and leukemic cells.

    MOLECULAR AND CELLULAR BIOLOGY 27 7073-7088. .

    [doi:10.1128/MCB.02116-06]

  • Caldero, Jordi; Tarabal, Olga; Casanovas, Anna; Ciutat, Dolors; Casas, Celia; Llado, Jeronia; Esquerda, Josep E.

    Excitotoxic motoneuron disease in chick embryo evolves with autophagic neurodegeneration and deregulation of neuromuscular innervation.

    Journal Of Neuroscience Research 85 2726-2740. .

    [doi:10.1002/jnr.21174]

  • Brunet, Nuria; Tarabal, Olga; Portero-Otin, Manel; Oppenheim, Ronald W.; Esquerda, Josep E.; Caldero, Jordi

    Survival and death of mature avian motoneurons in organotypic slice culture: trophic requirements for survival and different types of degeneration.

    Journal Of Comparative Neurology 501 669-690. .

    [doi:10.1002/cne.21157]

  • Tarabal, O; CALDERO, J; Casas, C; Oppenheim, RW; ESQUERDA, JE

    Protein retention in the endoplasmic reticulum, blockade of programmed cell death and autophagy selectively occur in spinal cord motoneurons after glutamate receptor-mediated injury.

    MOLECULAR AND CELLULAR NEUROSCIENCE 29 283-298. .

    [doi:10.1016/j.mcn.2005.03.003]

  • Oppenheim, RW; CALDERO, J; Cuitat, D; Esquerda, J; Ayala, V; Prevette, D; Wang, SW

    Rescue of developing spinal motoneurons from programmed cell death by the GABA(A) agonist muscimol acts by blockade of neuromuscular activity and increased intramuscular nerve branching.

    MOLECULAR AND CELLULAR NEUROSCIENCE 22 331-343. .

    [doi:10.1016/S1044-7431(02)00020-9]

Projectes

  • Preclinical Analisis of new combinatorial treatments for spinal muscular atrophy (SMA): Effects on motorneuron survival, synaptic integrity, and skeletal muscle preservation.
  • El sistema NRG1-ErbBs en la arquitectura molecular de las sinapsis aferentes de tipo C y su significado en las enfermedades de la motoneurona
  • Los aferentes sinápticos de tipo C en las motoneuronas: implicaciones en la fisiopatología y terapia de la esclerosis lateral amiotrófica y de la atrofia muscular espinal (Motoneurona)
  • La esclerosis lateral amiotrófica como enfermedad proteinopática y neuroimflamatoria: estrategias de inmunoterapia (Vacunas y ELA)
  • Excitotoxicidad, plegamiento anómalo de proteinas y mecanismos inmunológicos en la esclerosis lateral amiotrófica
  • Mecanismes excitotòxics, resposta neuroinflamatòria i factors sèrics en l´esclerosi lateral amiotròfica humana i experimental