Directori de persones
Josep Enric Esquerda Colell

Josep Enric Esquerda Colell

Grau: Doctor/a

973 702 427
josep.esquerda(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/A-7377-2010

Grups

Publicacions

  • Cerveró C; Montull N; Tarabal O; Piedrafita L; Esquerda JE; Calderó J

    Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy

    NEUROTHERAPEUTICS 13 198-216. .

    [doi:10.1007/s13311-015-0399-x]

  • SABADO, J.; CASANOVAS, A.; Rodrigo, H.; Arqué, G.; ESQUERDA, J.

    ADVERSE EFFECTS OF A SOD1-PEPTIDE IMMUNOTHERAPY ON SOD1(G93A) MOUSE SLOW MODEL OF AMYOTROPHIC LATERAL SCLEROSIS

    NEUROSCIENCE 310 38-50. .

    [doi:10.1016/j.neuroscience.2015.09.027]

  • Gallart-Palau X; Tarabal O; Casanovas A; Sábado J; Correa FJ; Hereu M; Piedrafita L; Calderó J; Esquerda JE

    Neuregulin-1 is concentrated in the postsynaptic subsurface cistern of C-bouton inputs to alpha-motoneurons and altered during motoneuron diseases

    FASEB JOURNAL 28 3618-3632. .

    [doi:10.1096/fj.13-248583]

  • Tarabal O; Caraballo-Miralles V; Cardona-Rossinyol A; Correa FJ; Olmos G; Lladó J; Esquerda JE; Calderó J

    Mechanisms Involved in Spinal Cord Central Synapse Loss in a Mouse Model of Spinal Muscular Atrophy

    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 73 519-535. .

    [doi:10.1097/NEN.0000000000000074]

  • Sabado, Javier; Casanovas, Anna; Tarabal, Olga; Hereu, Marta; Piedrafita, Ldia; Caldero, Jordi; Esquerda, Josep E.

    Accumulation of Misfolded SOD1 in Dorsal Root Ganglion Degenerating Proprioceptive Sensory Neurons of Transgenic Mice with Amyotrophic Lateral Sclerosis

    BioMed Research International 2014 -. .

    [doi:10.1155/2014/852163]

  • Dachs E; Piedrafita L; Hereu M; Esquerda JE; Calderó J

    CHRONIC TREATMENT WITH LITHIUM DOES NOT IMPROVE NEUROMUSCULAR PHENOTYPE IN A MOUSE MODEL OF SEVERE SPINAL MUSCULAR ATROPHY

    NEUROSCIENCE 250 417-433. .

    [doi:10.1016/j.neuroscience.2013.07.026]

  • Sábado J; Casanovas A; HERNÁNDEZ, S.; Piedrafita L; Hereu M; Esquerda JE

    Immunodetection of Disease-Associated Conformers of Mutant Cu/Zn Superoxide Dismutase 1 Selectively Expressed in Degenerating Neurons in Amyotrophic Lateral Sclerosis

    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 72 646-661. .

    [doi:10.1097/NEN.0b013e318297fd10]

  • Martinez-Hernandez, Rebeca; Bernal, Sara; Also-Rallo, Eva; Alias, Laura; Jesus Barcelo, Ma; Hereu, Marta; Esquerda, Josep E.; Tizzano, Eduardo F.

    Synaptic defects in type I spinal muscular atrophy in human development

    JOURNAL OF PATHOLOGY 229 49-61. .

    [doi:10.1002/path.4080]

  • Texido, Laura; Hernandez, Sara; Martin-Satue, Mireia; Povedano, Monica; Casanovas, Anna; Esquerda, Josep; Marsal, Jordi; Solsona, Caries

    Sera from amyotrophic lateral sclerosis patients induce the non-canonical activation of NMDA receptors "in vitro".

    NEUROCHEMISTRY INTERNATIONAL 59 954-964. .

    [doi:10.1016/j.neuint.2011.07.006]

  • Dachs, Elisabet; Hereu, Marta; Piedrafita, Lidia; Casanovas, Anna; Caldero, Jordi; Esquerda, Josep E.

    Defective neuromuscular junction organization and postnatal myogenesis in mice with severe spinal muscular atrophy.

    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 70 444-461. .

    [doi:10.1097/NEN.0b013e31821cbd8b]

  • Hernandez, Sara; Texido, Laura; Caldero, Jordi; Ciutat, Dolors; Piedrafita, Lidia; Casanovas, Anna; Blasi, Joan; Solsona, Carles; Povedano, Monica; Rojas, Ricardo; Illa, Isabel; Caress, James; Prevette, David; Oppenheim, Ronald W.; Milligan, Carol; Esquerda, Josep E.

    Increased intramuscular nerve branching and inhibition of programmed cell death of chick embryo motoneurons by immunoglobulins from patients with motoneuron disease.

    Journal Of Neuroimmunology 229 157-168. .

    [doi:10.1016/j.jneuroim.2010.07.028]

  • Caldero, J.; Brunet, N.; Tarabal, O.; Piedrafita, L.; Hereu, M.; Ayala, V.; Esquerda, J. E.

    Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord.

    NEUROSCIENCE 165 1353-1369. .

    [doi:10.1016/j.neuroscience.2009.11.034]

Projectes

  • Preclinical Analisis of new combinatorial treatments for spinal muscular atrophy (SMA): Effects on motorneuron survival, synaptic integrity, and skeletal muscle preservation.
  • El sistema NRG1-ErbBs en la arquitectura molecular de las sinapsis aferentes de tipo C y su significado en las enfermedades de la motoneurona
  • Los aferentes sinápticos de tipo C en las motoneuronas: implicaciones en la fisiopatología y terapia de la esclerosis lateral amiotrófica y de la atrofia muscular espinal (Motoneurona)
  • La esclerosis lateral amiotrófica como enfermedad proteinopática y neuroimflamatoria: estrategias de inmunoterapia (Vacunas y ELA)
  • Excitotoxicidad, plegamiento anómalo de proteinas y mecanismos inmunológicos en la esclerosis lateral amiotrófica
  • Mecanismes excitotòxics, resposta neuroinflamatòria i factors sèrics en l´esclerosi lateral amiotròfica humana i experimental