Directory
Manuel Portero Otin

Manuel Portero Otin

Degree: PhD

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Groups

Publications

  • Erauskin, JL; Fourcade, S; Ferrer, I; Pamplona, R; Portero-Otin, M; Pujol, A

    ANTIOXIDANTS AS A THERAPEUTIC HOPE FOR X-LINKED ADRENOLEUKODYSTROPHY

    Glia 57 100-101. .

  • Caro, Pilar; Gomez, Jose; Sanchez, Ines; Garcia, Ruben; Lopez-Torres, Monica; Naudi, Alba; Portero-Otin, Manuel; Pamplona, Reinald; Barja, Gustavo

    Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver.

    Biogerontology 10 579-592. .

    [doi:10.1007/s10522-008-9200-4]

  • Gomez, Jose; Caro, Pilar; Sanchez, Ines; Naudi, Alba; Jove, Mariona; Portero-Otin, Manuel; Lopez-Torres, Monica; Pamplona, Reinald; Barja, Gustavo

    Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart.

    JOURNAL OF BIOENERGETICS AND BIOMEMBRANES 41 309-321. .

    [doi:10.1007/s10863-009-9229-3]

  • Martinez, Anna; Carmona, Margarita; Portero-Otin, Manuel; Naudi, Alba; Pamplona, Reinald; Ferrer, Isidre

    Type-dependent oxidative damage in frontotemporal lobar degeneration: cortical astrocytes are targets of oxidative damage (vol 67, pg 1122, 2008)

    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 68 112-112. .

  • Martinez, Anna; Carmona, Margarita; Portero-Otin, Manuel; Naudi, Alba; Pamplona, Reinald; Ferrer, Isidre

    Type-dependent oxidative damage in frontotemporal lobar degeneration: cortical astrocytes are targets of oxidative damage.

    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 67 1122-1136. .

    [doi:10.1097/NEN.0b013e31818e06f3]

  • Pamplona, Reinald; Naudi, Alba; Gavin, Rosalina; Pastrana, Miguel A.; Sajnani, Gustavo; Ilieva, Ekaterina V.; Antonio del Rio, Jose; Portero-Otin, Manuel; Ferrer, Isidre; Requena, Jesus R.

    Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease.

    FREE RADICAL BIOLOGY AND MEDICINE 45 1159-1166. .

    [doi:10.1016/j.freeradbiomed.2008.07.009]

  • Fourcade, Stephane; Lopez-Erauskin, Jone; Galino, Jorge; Duval, Carine; Naudi, Alba; Jove, Mariona; Kemp, Stephan; Villarroya, Francesc; Ferrer, Isidre; Pamplona, Reinald; Portero-Otin, Manuel; Pujol, Aurora

    Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy.

    HUMAN MOLECULAR GENETICS 17 1762-1773. .

    [doi:10.1093/hmg/ddn085]

  • Caro, Pilar; Gomez, Jose; Lopez-Torres, Monica; Sanchez, Ines; Naudi, Alba; Portero-Otin, Manuel; Pamplona, Reinald; Barja, Gustavo

    Effect of every other day feeding on mitochondrial free radical production and oxidative stress in mouse liver.

    REJUVENATION RESEARCH 11 621-629. .

    [doi:10.1089/rej.2008.0704]

  • Portero-Otin, Manuel; Pamplona, Reinald; Boada, Jordi; Jove, Mariona; Gonzalo, Hugo; Buleon, Marie; Linzc, Wolfgang; Schaefer, Stefan; Tack, Ivan; Girolami, Jean-Pierre

    Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic rats.

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 368 528-535. .

    [doi:10.1016/j.bbrc.2008.01.101]

  • Pamplona R; Ilieva E; Ayala V; Bellmunt MJ; Cacabelos D; Dalfo E; Ferrer I; Portero-Otin M

    Maillard reaction versus other nonenzymatic modifications in neurodegenerative processes.

    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1126 315-319. .

    [doi:10.1196/annals.1433.014]

  • Ilieva, Ekaterina V.; Ayala, VictorRia; Jove, Mariona; Dalfo, Esther; Cacabelos, Daniel; Povedano, Monica; Bellmunt, Maria Josep; Ferrer, Isidre; Pamplona, Reinald; Portero-Otin, Manuel

    Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis.

    BRAIN 130 3111-3123. .

    [doi:10.1093/brain/awm190]

  • Naudi, Alba; Caro, Pilar; Jove, Mariona; Gomez, Jose; Boada, Jordi; Ayala, Victoria; Portero-Otin, Manuel; Barja, Gustavo; Pamplona, Reinald

    Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain.

    REJUVENATION RESEARCH 10 473-484. .

    [doi:10.1089/rej.2007.0538]

Projects

  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID
  • Metabolismo lipidico intracelular, procesamiento de ARNm y estrés celular en la encrucijada de la fisiopatología de la esclerosis lateral amiotrófica
  • Identification of compounds for inhibition of ACE2 membrane expression
  • Determinació de components bioactius derivats de la microbiota mitjançant micromostreig
  • Reposicionamiento terapéutico dirigido a inhibición de expresión de ACE2 y de proteolisis de trímero S viral
  • Estrés celulares y alteraciones en los lipidomas neuronales, gliales y extracelulares en la fisiopatología de la esclerosis lateral amiotrófica.
  • "Imagenoma de l'Envelliment": Estudi observacional poblacional per definir biomarcadors d'imatge RM corporal integral i òmics que s'associen al procés d'envelliment i a factors de risc biopsicosocial en subjectes adults i que defineixen la seva trajectòria vital cap a un envelliment saludable o bé la fragilitat i discapacitat.
  • Gut microbiota profile after consumption of a patented fiber formulation
  • ESTRES CELULAR Y DESLOCALIZACION DE FACTORES TRANSCRIPCIONALES EN LA FISIOPATOLOGIA DE LA ELA