Directory
Manuel Portero Otin

Manuel Portero Otin

Degree: PhD

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Groups

Publications

  • Bjørndal B; Grimstad T; Cacabelos D; Nylund K; Aasprong OG; Omdal R; Portero-Otin M; Pamplona R; Lied GA; Hausken T; Berge RK

    Tetradecylthioacetic Acid Attenuates Inflammation and Has Antioxidative Potential During Experimental Colitis in Rats

    DIGESTIVE DISEASES AND SCIENCES 58 97-106. .

    [doi:10.1007/s10620-012-2321-2]

  • Gonzalo, Hugo; Brieva, Luis; Tatzber, Franz; Jove, Mariona; Cacabelos, Daniel; Cassanye, Anna; Lanau-Angulo, Lucia; Boada, Jordi; Serrano, Jose C. E.; Gonzalez, Cristina; Hernandez, Lourdes; Peralta, Silvia; Pamplona, Reinald; Portero-Otin, Manuel

    Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism

    JOURNAL OF NEUROCHEMISTRY 123 622-634. .

    [doi:10.1111/j.1471-4159.2012.07934.x]

  • Vigerust, Natalya Filipchuk; Cacabelos, Daniel; Burri, Lena; Berge, Kjetil; Wergedahl, Hege; Christensen, Bjorn; Portero-Otin, Manuel; Viste, Asgaut; Pamplona, Reinald; Berge, Rolf Kristian; Bjorndal, Bodil

    Fish oil and 3-thia fatty acid have additive effects on lipid metabolism but antagonistic effects on oxidative damage when fed to rats for 50 weeks

    JOURNAL OF NUTRITIONAL BIOCHEMISTRY 23 1384-1393. .

    [doi:10.1016/j.jnutbio.2011.08.006]

  • Portero-Otin, M; Cacabelos, D; Jove, M; Ayala, V; Naudi, A; Ferrer, I; Pamplona, R

    Lipid peroxidizability as a potential trade-off of increased tissular docosahexaenoic acid concentrations in neurodegenerative processes

    FEBS Journal 279 219-220. .

  • Galea, Elena; Launay, Nathalie; Portero-Otin, Manuel; Ruiz, Montserrat; Pamplona, Reinald; Aubourg, Patrick; Ferrer, Isidre; Pujol, Aurora

    Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1822 1475-1488. .

    [doi:10.1016/j.bbadis.2012.02.005]

  • Aso, Ester; Lomoio, Selene; Lopez-Gonzalez, Irene; Joda, Laura; Carmona, Margarita; Fernandez-Yaguee, Nuria; Moreno, Jesus; Juves, Salvador; Pujol, Aurora; Pamplona, Reinald; Portero-Otin, Manuel; Martin, Virginia; Diaz, Mario; Ferrer, Isidro

    Amyloid Generation and Dysfunctional Immunoproteasome Activation with Disease Progression in Animal Model of Familial Alzheimer's Disease

    BRAIN PATHOLOGY 22 636-653. .

    [doi:10.1111/j.1750-3639.2011.00560.x]

  • Soler-Cantero, Arantza; Jove, Mariona; Cacabelos, Daniel; Boada, Jordi; Naudi, Alba; Romero, Maria-Paz; Cassanye, Anna; Serrano, Jose C. E.; Arola, Lluis; Valls, Josep; Josep Bellmunt, Maria; Prat, Joan; Pamplona, Reinald; Portero-Otin, Manuel; Motilva, Maria-Jose

    Plant-Derived Phenolics Inhibit the Accrual of Structurally Characterised Protein and Lipid Oxidative Modifications

    PLOS ONE 7 -. .

    [doi:10.1371/journal.pone.0043308]

  • Naudi, Alba; Jove, Mariona; Ayala, Victoria; Cassanye, Anna; Serrano, Jose; Gonzalo, Hugo; Boada, Jordi; Prat, Joan; Portero-Otin, Manuel; Pamplona, Reinald

    Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress

    EXPERIMENTAL DIABETES RESEARCH 2012 696215-696215. .

    [doi:10.1155/2012/696215]

  • Grimstad, Tore; Bjorndal, Bodil; Cacabelos, Daniel; Aasprong, Ole Gunnar; Janssen, Emiel A. M.; Omdal, Roald; Svardal, Asbjorn; Hausken, Trygve; Bohov, Pavol; Portero-Otin, Manuel; Pamplona, Reinald; Berge, Rolf K.

    Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 47 49-58. .

    [doi:10.3109/00365521.2011.634025]

  • Sanchez-Roman, Ines; Gomez, Alexia; Gomez, Jose; Suarez, Henar; Sanchez, Carlota; Naudi, Alba; Ayala, Victoria; Portero-Otin, Manuel; Lopez-Torres, Monica; Pamplona, Reinald; Barja, Gustavo

    Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart.

    JOURNAL OF BIOENERGETICS AND BIOMEMBRANES 43 699-708. .

    [doi:10.1007/s10863-011-9389-9]

  • Galino, Jorge; Ruiz, Montserrat; Fourcade, Stephane; Schlueter, Agatha; Lopez-Erauskin, Jone; Guilera, Cristina; Jove, Mariona; Naudi, Alba; Garcia-Arumi, Elena; Andreu, Antoni L.; Starkov, Anatoly A.; Pamplona, Reinald; Ferrer, Isidre; Portero-Otin, Manuel; Pujol, Aurora

    Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy.

    ANTIOXIDANTS & REDOX SIGNALING 15 2095-2107. .

    [doi:10.1089/ars.2010.3877]

  • Ayala, Victoria; Belen Granado-Serrano, Ana; Cacabelos, Daniel; Naudi, Alba; Ilieva, Ekaterina V.; Boada, Jordi; Caraballo-Miralles, Victor; Llado, Jeronia; Ferrer, Isidro; Pamplona, Reinald; Portero-Otin, Manuel

    Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS.

    ACTA NEUROPATHOLOGICA 122 259-270. .

    [doi:10.1007/s00401-011-0850-y]

Projects

  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID
  • Metabolismo lipidico intracelular, procesamiento de ARNm y estrés celular en la encrucijada de la fisiopatología de la esclerosis lateral amiotrófica
  • Identification of compounds for inhibition of ACE2 membrane expression
  • Determinació de components bioactius derivats de la microbiota mitjançant micromostreig
  • Reposicionamiento terapéutico dirigido a inhibición de expresión de ACE2 y de proteolisis de trímero S viral
  • Estrés celulares y alteraciones en los lipidomas neuronales, gliales y extracelulares en la fisiopatología de la esclerosis lateral amiotrófica.
  • "Imagenoma de l'Envelliment": Estudi observacional poblacional per definir biomarcadors d'imatge RM corporal integral i òmics que s'associen al procés d'envelliment i a factors de risc biopsicosocial en subjectes adults i que defineixen la seva trajectòria vital cap a un envelliment saludable o bé la fragilitat i discapacitat.
  • Gut microbiota profile after consumption of a patented fiber formulation
  • ESTRES CELULAR Y DESLOCALIZACION DE FACTORES TRANSCRIPCIONALES EN LA FISIOPATOLOGIA DE LA ELA