Directory
Juan Verdaguer Autonell

Juan Verdaguer Autonell

Degree: PhD

973 702 210
joan.verdaguer(ELIMINAR)@udl.cat

Publications

  • Carrillo, Jorge; Puertas, Maria Carmen; Planas, Raquel; Pastor, Xavier; Alba, Aurora; Stratmann, Thomas; Pujol-Borrell, Ricardo; Ampudia, Rosa Maria; Vives-Pi, Marta; Verdaguer, Joan

    Anti-peripherin B lymphocytes are positively selected during diabetogenesis.

    MOLECULAR IMMUNOLOGY 45 3152-3162. .

    [doi:10.1016/j.molimm.2008.03.003]

  • Alba, A.; Planas, R.; Clemente, X.; Carrillo, J.; Ampudia, R.; Puertas, M. -C.; Pastor, X.; Tolosa, E.; Pujol-Borrell, R.; Verdaguer, J.; Vives-Pi, M.

    Natural killer cells are required for accelerated type 1 diabetes driven by interferon-beta.

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY 151 467-475. .

    [doi:10.1111/j.1365-2249.2007.03580.x]

  • Planas, R.; Carrillo, J.; Clemente, X.; Verdaguer, J.; Pajol-Borrell, R.; Vives-Pi, M.

    Gene expression analysis by microarrays in a human pancreas at the onset of autoimmune diabetes

    Acta diabetologica 44 41-41. .

  • Puertas, Maria Carmen; Carrillo, Jorge; Pastor, Xavier; Ampudia, Rosa Maria; Planas, Raquel; Alba, Aurora; Bruno, Roxana; Pujol-Borrell, Ricardo; Estanyol, Josep Maria; Vives-Pi, Marta; Verdaguer, Joan

    Peripherin is a relevant neuroendocrine autoantigen recognized by islet-infiltrating B lymphocytes.

    JOURNAL OF IMMUNOLOGY 178 6533-6539. .

  • Carmen Puertas, Maria; Carrillo, Jorge; Pastor, Xavier; Ampudia, Rosa Maria; Alba, Aurora; Planas, Raquel; Pujol-Borrell, Ricardo; Vives-Pi, Marta; Verdaguer, Joan

    Phenotype and functional characteristics of islet-infiltrating B-cells suggest the existence of immune regulatory mechanisms in islet milieu.

    Diabetes 56 940-949. .

    [doi:10.2337/db06-0428]

  • Planas, R.; Alba, A.; Carrillo, J.; Puertas, M. C.; Ampudia, R.; Pastor, X.; Okamoto, H.; Takasawa, S.; Gurr, W.; Pujol-Borrell, R.; Verdaguer, J.; Vives-Pi, M.

    Reg (regenerating) gene overexpression in islets from non-obese diabetic mice with accelerated diabetes: role of IFNbeta.

    Diabetologia 49 2379-2387. .

    [doi:10.1007/s00125-006-0365-6]

  • Palomer, X; Calpe-Berdiel, L; Verdaguer, J; Carrillo, J; Pastor, X; Mauricio, D; Blanco-Vaca, F

    Atorvastatin does not decrease or delay diabetes onset in two different mouse models of type 1 diabetes.

    Diabetologia 48 1671-1673. .

    [doi:10.1007/s00125-005-1834-z]

  • Carrillo, J; Puertas, MC; Alba, A; Ampudia, RM; Pastor, X; Planas, R; Riutort, N; Alonso, N; Pujol-Borrell, R; Santamaria, P; Vives-Pi, M; Verdaguer, J

    Islet-infiltrating B-cells in nonobese diabetic mice predominantly target nervous system elements.

    Diabetes 54 69-77. .

    [doi:10.2337/diabetes.54.1.69]

  • Alba, A; Puertas, MC; Carrillo, J; Planas, R; Ampudia, R; Pastor, X; Bosch, F; Pujol-Borrell, R; Verdaguer, J; Vives-Pi, M

    IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.

    JOURNAL OF IMMUNOLOGY 173 6667-6675. .

  • Yamanouchi, J; Verdaguer, J; Han, B; Amrani, A; Serra, P; Santamaria, P

    Cross-priming of diabetogenic T cells dissociated from CTL-induced shedding of beta cell autoantigens.

    JOURNAL OF IMMUNOLOGY 171 6900-6909. .

  • Serra, P; Amrani, A; Yamanouchi, J; Han, BY; Thiessen, S; Utsugi, T; Verdaguer, J; Santamaria, P

    CD40 ligation releases immature dendritic cells from the control of regulatory CD4(+)CD25(+) T cells

    Immunity 19 877-889. .

    [doi:10.1016/S1074-7613(03)00327-3]

  • Yamanouchi, J; Verdaguer, J; Han, B; Amrani, A; Serra, P; Santamaria, P

    Fas-dependent killing of beta cells by diabetogenic CD8+T lymphocytes in vivo requires a cognate interaction between effector lymphocytes and their targets

    Diabetes 51 90-90. .

Projects

  • Estudio del impacto generado por modificaciones en la microbiota intestinal sobre la actividad del sistema inmune en el modelo murino NOD de diabetes autoinmune.
  • OncoNeoVac, un nuevo enfoque inmunoterapéutico para el tratamiento del melanoma.
  • INVESTIGO 2022: Grup de Recerca en Immunologia i Metabolisme (GRIM)
  • Modelación de la microbiota intestinal en las etapas iniciales del desarrollo de la diabetes autoinmune en el ratón NOD, modelo de la diabetes tipo 1 humana.
  • Estudi de l'efecte adjuvant de DIF-P en una vacuna antigripal
  • Linfocitos T y B anti-periferina y anti-cromogranina T and B lymphocyte durante el desarrollo de la Diabetes Mellitus Tipo 1 (APACT1D)
  • Linfocitos B y T autoreactivos en la diabetes del tipo 1: Análisis funcional y desarrollo de estrategias de tratamiento (BATINT1D)
  • CARACTERIZACIÓN DE LA RESPUESTA DE LINFOCITOS B AUTOREACTIVOS CONTRA UN NUEVO AUTOANTIGENO DE 90 KDA ESPECIFICO DE CELULAS BETA PANCREATICAS DURANTE EL DESARROLLO DE LA DIABETES TIPO 1
  • IDENTIFICACIO DEL NOU AUTOANTIGEN ICA85 I CARACTERITZACIO DE LA RESPOSTA AUTOINMUNITARIA CONTRA AQUEST EN PACIENTS AMB DIABETIS TIPUS 1