Directori de persones
Reinald Pamplona Gras

Reinald Pamplona Gras

Grau: Doctor/a

973 702 442
reinald.pamplona(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/A-7359-2010

Publicacions

  • Naudi, Alba; Caro, Pilar; Jove, Mariona; Gomez, Jose; Boada, Jordi; Ayala, Victoria; Portero-Otin, Manuel; Barja, Gustavo; Pamplona, Reinald

    Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain.

    REJUVENATION RESEARCH 10 473-484. .

    [doi:10.1089/rej.2007.0538]

  • Cantero, Anne-Valerie; Portero-Otin, Manuel; Ayala, Victoria; Auge, Nathalie; Sanson, Marie; Elbaz, Meyer; Thiers, Jean-Claude; Pamplona, Reinald; Salvayre, Robert; Negre-Salvayre, Anne

    Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis.

    FASEB JOURNAL 21 3096-3106. .

    [doi:10.1096/fj.06-7536com]

  • Pamplona, Reinald; Barja, Gustavo

    Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevity.

    AGEING RES REV 6 189-210. .

    [doi:10.1016/j.arr.2007.06.002]

  • Gomez, Jose; Caro, Pilar; Naudi, Alba; Portero-Otin, Manuel; Pamplona, Reinald; Barja, Gustavo

    Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver.

    Biogerontology 8 555-566. .

    [doi:10.1007/s10522-007-9099-1]

  • Naudi, A; Jove, M; Caro, P; Gomez, J; Lopez-Torres, M; Sanchez, I; Barja, G; Pamplona, R

    40% and 80% methionine restriction without changing other dietary components decrease oxidative stress in rat liver

    FREE RADICAL RESEARCH 41 44-44. .

  • Hulbert, A. J.; Pamplona, Reinald; Buffenstein, Rochelle; Buttemer, W. A.

    Life and death: metabolic rate, membrane composition, and life span of animals.

    PHYSIOL REV 87 1175-1213. .

    [doi:10.1152/physrev.00047.2006]

  • Ilieva, E; Naudi, A; Dalfo, E; Ayala, V; Ferrer, I; Portero-Otin, M; Pamplona, R

    Implication of oxidative and endoplasmic reticulum stress in Pick's disease

    FREE RADICAL RESEARCH 41 33-33. .

  • Ayala, Victoria; Naudi, Alba; Sanz, Alberto; Caro, Pilar; Portero-Otin, Manuel; Barja, Gustavo; Pamplona, Reinald

    Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver.

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 62 352-360. .

  • Caro, Pilar; Gomez, Jose; Sanz, Alberto; Portero-Otin, Manel; Pamplona, Reinald; Barja, Gustavo

    Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria.

    Biogerontology 8 1-11. .

    [doi:10.1007/s10522-006-9026-x]

  • Muntane, G.; Dalfo, E.; Martinez, A.; Rey, M. J.; Avila, J.; Perez, M.; Portero, M.; Pamplona, R.; Ayala, V.; Ferrer, I.

    Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease.

    JOURNAL OF NEUROCHEMISTRY 99 177-185. .

    [doi:10.1111/j.1471-4159.2006.04032.x]

  • Sanz, Alberto; Caro, Pilar; Ayala, Victoria; Portero-Otin, Manuel; Pamplona, Reinald; Barja, Gustavo

    Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins.

    FASEB JOURNAL 20 1064-1073. .

    [doi:10.1096/fj.05-5568com]

  • Pamplona, R.; Barja, G.

    Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1757 496-508. .

    [doi:10.1016/j.bbabio.2006.01.009]

Projectes

  • La vía de señalización mediada por los lípidos bioactivos diacilglicerol-ácido fosfatídico como biomarcadores para discriminar los estadios iniciales de la enfermedad de Alzheimer del envejecimiento normal
  • Identification of compounds for inhibition of ACE2 membrane expression
  • Dynamics of the neuronal, metabolomic and neuropsychological signatures underlying the adptations for motherhood during pregnancy. (babybrain)
  • Neurolipidómica del envejecimiento cerebral humano
  • "Imagenoma de l'Envelliment": Estudi observacional poblacional per definir biomarcadors d'imatge RM corporal integral i òmics que s'associen al procés d'envelliment i a factors de risc biopsicosocial en subjectes adults i que defineixen la seva trajectòria vital cap a un envelliment saludable o bé la fragilitat i discapacitat.
  • IDENTIFYING PREDICTORS OF CARDIOVASCULAR EVENTS IN CHRONIC KIDNEY DISEASE. A COHORTS SUBSTUDY WITHIN THE NEFRONA STUDY
  • Interactomas y marcadores para discriminar factores de vulnerabilidad neuronal regional en la neurodegeneración asociada al envejecimiento normal y patológico en el SNC
  • IDENTIFICACION DE BIOMARCADORES LIPIDICOS EN LIQUIDO CEFALORRAQUIDEO COMO PREDICTORES DEL DESARROLLO DE LA ENFERMEDAD DE ALZHEIMER EN PACIENTES CON DETERIORO COGNITIVO LEVE
  • ESTRES OXIDATIVO E INFLAMACION EN LA EVOLUCION DEL PROCESO DE ENVEJECIMIENTO Y PROGRESION DE LA ENFERMEDAD DE ALZHEIMER EN DIFERENTES REGIONES DEL SISTEMA NERVIOSO CENTRAL HUMANO
  • PEGASO - Personalised Guidance Services for Optimising lifesstyle in teenagers through awareness, motivation and engagement
  • CONVOCATORIA D'AJUTS PER A PERSONAL PREDOCTORAL DEL IRBLLEIDA "FUNDACIO LA CAIXA"
  • Papel de la composicion de membrana en el envejecimiento y la determinacion de la longevidad: una aproximacion lipidomica y proteomica