Directori de persones
Concepción Mora Giral

Concepción Mora Giral

Grau: Doctor/a

973 702 958
conchi.mora(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/A-8280-2010

Grups

Publicacions

  • Altirriba, Jordi; Garcia, Ainhoa; Sanchez, Begona; Haba, Laura; Altekruse, Sean; Stratmann, Thomas; Antoni Bombi, Josep; Mezquita, Cristobal; Gomis, Ramon; Mora, Conchi

    The sole presence of CDK4 is not a solid criterion for discriminating between tumor and healthy pancreatic tissues

    INTERNATIONAL JOURNAL OF CANCER 130 2743-2745. .

    [doi:10.1002/ijc.26313]

  • Wen, Li; Green, Elizabeth A.; Stratmann, Thomas; Panosa, Anais; Gomis, Ramon; Eynon, Elizabeth E.; Flavell, Richard A.; Mezquita, Jovita A.; Mora, Conchi

    In vivo diabetogenic action of CD4+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18.

    EUROPEAN JOURNAL OF IMMUNOLOGY 41 1344-1351. .

    [doi:10.1002/eji.201041216]

  • Rivas, Elisa I.; Driver, John P.; Garabatos, Nahir; Presa, Maximiliano; Mora, Conchi; Rodriguez, Fernando; Serreze, David V.; Stratmann, Thomas

    Targeting of a T Cell Agonist Peptide to Lysosomes by DNA Vaccination Induces Tolerance in the Nonobese Diabetic Mouse

    JOURNAL OF IMMUNOLOGY 186 4078-4087. .

    [doi:10.4049/jimmunol.0902395]

  • Marzo, Nuria; Ortega, Sagrario; Stratmann, Thomas; Garcia, Ainhoa; Rios, Martin; Gimenez, America; Gomis, Ramon; Mora, Conchi

    Cyclin-dependent kinase 4 hyperactivity promotes autoreactivity in the immune system but protects pancreatic beta cell mass from autoimmune destruction in the nonobese diabetic mouse model

    JOURNAL OF IMMUNOLOGY 180 1189-1198. .

  • Marzo N; Ortega S; Stratmann T; García A; Ríos M; Giménez A; Gomis R; Mora C

    Cyclin-dependent kinase 4 hyperactivity promotes autoreactivity in the immune system but protects pancreatic cell mass from autoimmune destruction in the nonobese diabetic mouse model.

    JOURNAL OF IMMUNOLOGY 180 1189-1198. .

  • Kwon, H; Jun, HS; Yang, Y; Mora, C; Mariathasan, S; Ohashi, PS; Flavell, RA; Yoon, JW

    Development of autoreactive diabetogenic T cells in the thymus of NOD mice.

    Journal Of Autoimmunity 24 11-23. .

    [doi:10.1016/j.jaut.2004.10.002]

  • Marzo, N; Mora, C; Fabregat, ME; Martin, J; Usac, EF; Franco, C; Barbacid, M; Gomis, R

    Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes.

    Diabetologia 47 686-694. .

    [doi:10.1007/s00125-004-1372-0]

  • Mora, C; Grewal, IS; Wong, FS; Flavell, RA

    Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice.

    INT IMMUNOL 16 257-264. .

    [doi:10.1093/intimm/dxh036]

  • Eshima, K; Mora, C; Wong, FS; Green, EA; Grewal, IS; Flavell, RA

    A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes mellitus in the non-obese diabetic mouse.

    INT IMMUNOL 15 351-357. .

    [doi:10.1093/intimm/dxg035]

  • Wen, L; Wong, FS; Sherwin, R; Mora, C

    Human DQ8 can substitute for murine I-a(g7) in the selection of diabetogenic T cells restricted to I-a(g71)

    JOURNAL OF IMMUNOLOGY 168 3635-3640. .

  • Wen L; Wong FS; Sherwin R; Mora C

    Human DQ8 can substitute for murine I-Ag7 in the selection of diabetogenic T cells restricted to I-Ag7.

    JOURNAL OF IMMUNOLOGY 168 3635-3640. .

  • Gurr, W; Yavari, R; Wen, L; Shaw, M; Mora, C; Christa, L; Sherwin, RS

    A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice.

    Diabetes 51 339-346. .

Projectes

  • INVESTIGO 2022: Grup de Recerca en Immunologia i Metabolisme (GRIM)
  • DendriTHERAP: Anàlisi Transcriptòmica de cèl·lules dendrítiques novells per tal de dissenyar una teràpia per a la diabetis autoimmune
  • Validación de la Ciclina D3 como regulador-clave de: la apoptosis debida a estrés del retículo endoplásmico y la función mitocondrial de la célula beta-pancreática en la diabetes (T1D).
  • Identificación de nuevas vías de señalización de la ciclina D3 responsables del bienestar metabólico y viabilidad de las células beta pancreáticas en la diabetes autoinmune
  • Estudi de la ciclina D3 i la CDK11 com a dianes moleculars de l'atac autoimmune vers les cél·lules beta-pancreàtiques a la diabetis de tipus 1(T1D). Determinació i caracterització de la relació causal entre la repressió de ciclina D3 i CDK11 i la mort de les cèl·lules beta-pancreàtiques.
  • IMMUNOSUPRESSIO AUTOLOGA I ANTIGEN-ESPECIFICA EN LA T1DM: GENERACIO EX VIVO DE LIMFOCITS T CD4+ REGULADORS Tr1 ESPECIFICS PER A LA INSULINA AUTOLEGS MITJANÇANT CEL·LULES DENDRITIQUES (DCs)
  • Estudio de la expresión diferencial de genes implicados en el ciclo celular beta-pancreático asociada a la insulitis existente en la diabetes de tipo 1 (T1D)
  • Estudio de la expresión diferencial de genes implicados en el ciclo celular beta-pancraático asociada a la insulitis existente en la diabetes de Tipo 1 (T1D)