Manuel Portero Otin

Pamplona, R; Portero-Otin, M; Sanz, A; Requena, J; Barja, G

Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain.

EXPERIMENTAL GERONTOLOGY 39 725-733. 01/05/2004.

[doi:10.1016/j.exger.2004.01.006]

Portero-Otin, M; Bellmunt, MJ; Requena, JR; Pamplona, R

Protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids.

BIOCHEMICAL SOCIETY TRANSACTIONS 31 1403-1405. 01/12/2003.

[doi:10.1042/bst0311403]

Echtay, KS; Esteves, TC; Pakay, JL; Jekabsons, MB; Lambert, AJ; Portero-Otin, M; Pamplona, R; Vidal-Puig, AJ; Wang, S; Roebuck, SJ; Brand, MD

A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling.

EMBO JOURNAL 22 4103-4110. 15/08/2003.

[doi:10.1093/emboj/cdg412]

Ruiz, MC; Portero-Otin, M; Pamplona, R; Requena, JR; Prat, J; Lafarga, MA; Borras, M; Bellmunt, MJ

Chemical and immunological characterization of oxidative nonenzymatic protein modifications in dialysis fluids.

PERITONEAL DIALYSIS INTERNATIONAL 23 23-32. 01/01/2003.

Brand, MD; Pamplona, R; Portero-Otin, M; Requena, JR; Roebuck, SJ; Buckingham, JA; Clapham, JC; Cadenas, S

Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3.

BIOCHEMICAL JOURNAL 368 597-603. 01/12/2002.

[doi:10.1042/BJ20021077]

Pamplona, R; Portero-Otin, M; Requena, J; Gredilla, R; Barja, G

Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls.

MECHANISMS OF AGEING AND DEVELOPMENT 123 1437-1446. 01/09/2002.

[doi:10.1016/S0047-6374(02)00076-3]

Portero-Otin, M; Pamplona, R; Bellmunt, MJ; Ruiz, MC; Prat, J; Salvayre, R; Negre-Salvayre, A

Advanced glycation end product precursors impair epidermal growth factor receptor signaling.

DIABETES 51 1535-1542. 01/05/2002.

[doi:10.2337/diabetes.51.5.1535]

Pamplona R; Barja G; PORTERO OTIN, MANUEL

Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation?

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 959 475-490. 01/04/2002.

[doi:10.1111/j.1749-6632.2002.tb02118.x]

Doñate T; Herreros A; Martinez E; Martinez J; Andrés E; Cabezas A; Ortiz A; de Prado A; Pou JM; Pamplona R; Portero Otin M; Bellmunt MJ

Protein oxidative stress in dialysis patients.

Advances In Peritoneal Dialysis. Conference On Peritoneal Dialysis 18 15-17. 01/01/2002.

Pamplona, R; Portero-Otin, M; Bellmunt, MJ; Gredilla, R; Barja, G

Aging increases N(epsilon)-(carboxymethyl)lysine and caloric restriction decreases N(epsilon)-(carboxyethyl)lysine and N(epsilon)-(malondialdehyde)lysine in rat heart mitochondrial proteins

FREE RADICAL RESEARCH 36 47-54. 01/01/2002.

[doi:10.1080/10715760290001281]

Portero-Otin, M; Bellmunt, MJ; Ruiz, MC; Barja, G; Pamplona, R

Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential.

LIPIDS 36 491-498. 01/05/2001.

[doi:10.1007/s11745-001-0748-y]

Gredilla, R; Lopez Torres, M; Portero-Otin, M; Pamplona, R; Barja, G

Influence of hyper- and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle.

MOLECULAR AND CELLULAR BIOCHEMISTRY 221 41-48. 01/05/2001.

[doi:10.1023/A:1010930110382]