Directorio de personas
Manuel Portero Otin

Manuel Portero Otin

Grado: Doctor/a

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Grupos

Publicaciones

  • Serrano, Jose; Cipak, Ana; Boada, Jordi; Gonzalo, Hugo; Cacabelos, Daniel; Cassanye, Anna; Pamplona, Reinald; Zarkovic, Neven; Portero-Otin, Manuel

    Double-edged sword behaviour of gallic acid and its interaction with peroxidases in human microvascular endothelial cell culture (HMEC-1). Antioxidant and pro-oxidant effects.

    ACTA BIOCHIMICA POLONICA 57 193-198. .

    [doi:10.18388/abp.2010_2394]

  • Sanz, Alberto; Soikkeli, Mikko; Portero-Otin, Manuel; Wilson, Angela; Kemppainen, Esko; McIlroy, George; Ellila, Simo; Kemppainen, Kia K.; Tuomela, Tea; Lakanmaa, Matti; Kiviranta, Essi; Stefanatos, Rhoda; Dufour, Eric; Hutz, Bettina; Naudi, Alba; Jove, Mariona; Zeb, Akbar; Vartiainen, Suvi; Matsuno-Yagi, Akemi; Yagi, Takao; Rustin, Pierre; Pamplona, Reinald; Jacobs, Howard T.

    Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107 9105-9110. .

    [doi:10.1073/pnas.0911539107]

  • Ilieva, Ekaterina V.; Naudi, Alba; Kichev, Anton; Ferrer, Isidre; Pamplona, Reinald; Portero-Otin, Manuel

    Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease.

    FREE RADICAL BIOLOGY AND MEDICINE 48 1302-1310. .

    [doi:10.1016/j.freeradbiomed.2010.02.006]

  • Fourcade, Stephane; Ruiz, Montserrat; Guilera, Cristina; Hahnen, Eric; Brichta, Lars; Naudi, Alba; Portero-Otin, Manuel; Dacremont, Georges; Cartier, Nathalie; Wanders, Ronald; Kemp, Stephan; Mandel, Jean Louis; Wirth, Brunhilde; Pamplona, Reinald; Aubourg, Patrick; Pujol, Aurora

    Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy.

    HUMAN MOLECULAR GENETICS 19 2005-2014. .

    [doi:10.1093/hmg/ddq082]

  • Naudí A; Jové M; Ayala V; Portero-Otín M; Pamplona R

    Glicación de proteínas mitocondriales, estrés oxidativo y envejecimiento.

    Revista espanola de geriatria y gerontologia 45 156-166. .

    [doi:10.1016/j.regg.2010.02.001]

  • Martinez, Anna; Portero-Otin, Manuel; Pamplona, Reinald; Ferrer, Isidre

    Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates.

    BRAIN PATHOLOGY 20 281-297. .

    [doi:10.1111/j.1750-3639.2009.00326.x]

  • Muntane, Gerard; Janue, Anna; Fernandez, Nuria; Odena, Maria Antonia; Oliveira, Eliandre; Boluda, Susana; Portero-Otin, Manuel; Naudi, Alba; Boada, Jordi; Pamplona, Reinald; Ferrer, Isidre

    Modification of brain lipids but not phenotype in alpha-synucleinopathy transgenic mice by long-term dietary n-3 fatty acids.

    NEUROCHEMISTRY INTERNATIONAL 56 318-328. .

    [doi:10.1016/j.neuint.2009.10.015]

  • Terni, Beatrice; Boada, Jordi; Portero-Otin, Manuel; Pamplona, Reinald; Ferrer, Isidro

    Mitochondrial ATP-synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer's disease pathology.

    BRAIN PATHOLOGY 20 222-233. .

    [doi:10.1111/j.1750-3639.2009.00266.x]

  • Fernandez, Liana Lisboa; Carmona, Marga; Portero-Otin, Manuel; Naudi, Alba; Pamplona, Reinald; Schroeder, Nadja; Ferrer, Isidro

    Effects of increased iron intake during the neonatal period on the brain of adult AbetaPP/PS1 transgenic mice.

    JOURNAL OF ALZHEIMERS DISEASE 19 1069-1080. .

    [doi:10.3233/JAD-2010-1304]

  • Quiles, Jose L.; Pamplona, Reinald; Carmen Ramirez-Tortosa, M.; Naudi, Alba; Portero-Otin, Manuel; Araujo-Nepomuceno, Eduardo; Lopez-Frias, Magdalena; Battino, Maurizio; Ochoa, Julio J.

    Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart.

    MECHANISMS OF AGEING AND DEVELOPMENT 131 38-47. .

    [doi:10.1016/j.mad.2009.11.004]

  • Kichev, Anton; Ilieva, Ekaterina V.; Pinol-Ripoll, Gerard; Podlesniy, Petar; Ferrer, Isidro; Portero-Otin, Manuel; Pamplona, Reinald; Espinet, Carme

    Cell death and learning impairment in mice caused by in vitro modified pro-NGF can be related to its increased oxidative modifications in Alzheimer disease.

    AMERICAN JOURNAL OF PATHOLOGY 175 2574-2585. .

    [doi:10.2353/ajpath.2009.090018]

  • Negre-Salvayre, Anne; Salvayre, Robert; Auge, Nathalie; Pamplona, Reinald; Portero-Otin, Manuel

    Hyperglycemia and glycation in diabetic complications.

    ANTIOXIDANTS & REDOX SIGNALING 11 3071-3109. .

    [doi:10.1089/ars.2009.2484]

Proyectos

  • Spanish Minor Stroke Perfusion Initiative: SMS-P Initiative
  • Contractació de personal investigador predoctoral en formació (FI SDUR 2024)
  • Ajuts Joan Oró per a la contractació de personal investigador predoctoral en formació FI 2025
  • SEED-ALS: Synergizing Efforts to Develop and Accelerate Breakthroughs in ALS Research
  • Natural microbicides from rice against current and emerging infectious diseases
  • Personal predoctoral en formació UdL 2025
  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • Targeting cryptic exons as biomarkers and ALS therapy
  • Comprehensive Roadmap and Preclinical Evaluation of Antisense Oligonucleotides (ASOs) Regulatory Development and Toxicological Assessment for ALS Treatment
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID