Directori de persones
Manuel Portero Otin

Manuel Portero Otin

Grau: Doctor/a

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Grups

Publicacions

  • Dominguez, M; de Oliveira, E; Odena, MA; Portero, M; Pamplona, R; Ferrer, I

    Redox proteomic profiling of neuroketal-adducted proteins in human brain: Regional vulnerability at middle age increases in the elderly

    FREE RADICAL BIOLOGY AND MEDICINE 95 1-15. .

    [doi:10.1016/j.freeradbiomed.2016.02.034]

  • Jové M; Maté I; Naudí A; Mota-Martorell N; Portero-Otín M; De la Fuente M; Pamplona R

    Human Aging Is a Metabolome-related Matter of Gender

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 71 578-585. .

    [doi:10.1093/gerona/glv074]

  • Pardo, L; Schluter, A; Valor, LM; Barco, A; Giralt, M; Golbano, A; Hidalgo, J; Jia, PL; Zhao, ZM; Jove, M; Portero-Otin, M; Ruiz, M; Gimenez-Llort, L; Masgrau, R; Pujol, A; Galea, E

    Targeted activation of CREB in reactive astrocytes is neuroprotective in focal acute cortical injury

    Glia 64 853-874. .

    [doi:10.1002/glia.22969]

  • Moreno-Navarrete, JM; Jove, M; Ortega, F; Xifra, G; Ricart, W; Obis È; Pamplona, R; Portero-Otin, M; Fernandez-Real, JM

    Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity

    Diabetologia 59 822-832. .

    [doi:10.1007/s00125-016-3863-1]

  • Cacabelos, D; Ayala, V; Granado-Serrano, AB; Jove, M; Torres, P; Boada, J; Cabre, R; Ramirez-Nunez, O; Gonzalo, H; Soler-Cantero, A; Serrano, JCE; Bellmunt, MJ; Romero, MP; Motilva, MJ; Nonaka, T; Hasegawa, M; Ferrer, I; Pamplona, R; Portero-Otin, M

    Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis

    NEUROBIOLOGY OF DISEASE 88 148-160. .

    [doi:10.1016/j.nbd.2016.01.007]

  • Eritja, N; Arjo, G; Santacana, M; Gatius, S; Ramirez-Nunez, O; Arcal, L; Serrano, JCE; Pamplona, R; Dolcet, X; Pinol, C; Christou, P; Matias-Guiu, X; Portero-Otin, M

    Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1862 526-535. .

    [doi:10.1016/j.bbadis.2016.01.018]

  • Cacabelos, D; Ramirez-Nunez, O; Granado-Serrano, AB; Torres, P; Ayala, V; Moiseeva, V; Povedano, M; Ferrer, I; Pamplona, R; Portero-Otin, M; Boada, J

    Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS

    Acta neuropathologica communications 4 3-3. .

    [doi:10.1186/s40478-015-0271-6]

  • Nogareda C; Moreno JA; Angulo E; Sandmann G; Portero M; Capell T; Zhu C; Christou P

    Carotenoid-enriched transgenic corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis

    PLANT BIOTECHNOLOGY JOURNAL 14 160-168. .

    [doi:10.1111/pbi.12369]

  • Fernandez-Real JM; Serino M; Blasco G; Puig J; Daunis-I-Estadella J; Ricart W; Burcelin R; Fernández-Aranda F; Portero-Otin M

    Gut Microbiota Interacts With Brain Microstructure and Function

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 100 4505-4513. .

    [doi:10.1210/jc.2015-3076]

  • Morató L; Ruiz M; Boada J; Calingasan NY; Galino J; Guilera C; Jové M; Naudí A; Ferrer I; Pamplona R; Serrano M; Portero-Otín M; Beal MF; Fourcade S; Pujol A

    Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy

    CELL DEATH AND DIFFERENTIATION 22 1742-1753. .

    [doi:10.1038/cdd.2015.20]

  • Mar Rodríguez M; Pérez D; Javier Chaves F; Esteve E; Marin-Garcia P; Xifra G; Vendrell J; Jové M; Pamplona R; Ricart W; Portero-Otin M; Chacón MR; Fernández Real JM

    Obesity changes the human gut mycobiome

    SCIENTIFIC REPORTS 5 14600-14600. .

    [doi:10.1038/srep14600]

  • López-González I; Aso E; Carmona M; Armand-Ugon M; Blanco R; Naudí A; Cabré R; Portero-Otin M; Pamplona R; Ferrer I

    Neuroinflammatory Gene Regulation, Mitochondrial Function, Oxidative Stress, and Brain Lipid Modifications With Disease Progression in Tau P301S Transgenic Mice as a Model of Frontotemporal Lobar Degeneration-Tau

    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 74 975-999. .

    [doi:10.1097/NEN.0000000000000241]

Projectes

  • Natural microbicides from rice against current and emerging infectious diseases
  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Targeting cryptic exons as biomarkers and ALS therapy
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID
  • Metabolismo lipidico intracelular, procesamiento de ARNm y estrés celular en la encrucijada de la fisiopatología de la esclerosis lateral amiotrófica
  • Identification of compounds for inhibition of ACE2 membrane expression
  • Reposicionamiento terapéutico dirigido a inhibición de expresión de ACE2 y de proteolisis de trímero S viral
  • Determinació de components bioactius derivats de la microbiota mitjançant micromostreig
  • Estrés celulares y alteraciones en los lipidomas neuronales, gliales y extracelulares en la fisiopatología de la esclerosis lateral amiotrófica.
  • "Imagenoma de l'Envelliment": Estudi observacional poblacional per definir biomarcadors d'imatge RM corporal integral i òmics que s'associen al procés d'envelliment i a factors de risc biopsicosocial en subjectes adults i que defineixen la seva trajectòria vital cap a un envelliment saludable o bé la fragilitat i discapacitat.