Directori de persones
Manuel Portero Otin

Manuel Portero Otin

Grau: Doctor/a

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Publicacions

  • Planas-Serra L; Launay N; Goicoechea L; Heron B; Jou C; Juliá-Palacios N; Ruiz M; Fourcade S; Casasnovas C; De La Torre C; Gelot A; Marsal M; Loza-Alvarez P; García-Cazorla À; Fatemi A; Ferrer I; Portero-Otin M; Area-Gómez E; Pujol A

    Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity.

    JOURNAL OF CLINICAL INVESTIGATION 133 -. .

    [doi:10.1172/JCI162957]

  • Obis, E; Sol, J; Andres-Benito, P; Martin-Gari, M; Mota-Martorell, N; Galo-Licona, JD; Piñol-Ripoll G; Portero-Otin, M; Ferrer, I; Jove, M; Pamplona, R

    Lipidomic Alterations in the Cerebral Cortex and White Matter in Sporadic Alzheimer's Disease.

    Aging and Disease 14 1887-1916. .

    [doi:10.14336/AD.2023.0217]

  • Muñoz-Basagoiti J; Monteiro FLL; Krumpe LRH; Armario-Najera V; Shenoy SR; Perez-Zsolt D; Westgarth HJ; Villorbina G; Bomfim LM; Raïch-Regué D; Nogueras L; Henrich CJ; Gallemí M; Moreira FRR; Torres P; Wilson J; D'arc M; Marfil S; Herlinger AL; Pradenas E; Higa LM; Portero-Otin M; Trinité B; Twyman RM; Capell T; Tanuri A; Blanco J; Izquierdo-Useros N; Rech EL; Christou P; O'Keefe BR

    Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 120 -. .

    [doi:10.1073/pnas.2214561120]

  • Jové M; Mota-Martorell N; Obis È; Sol J; Martín-Garí M; Ferrer I; Portero-Otin M; Pamplona R

    Ether Lipid-Mediated Antioxidant Defense in Alzheimer's Disease.

    Antioxidants 12 -. .

    [doi:10.3390/antiox12020293]

  • Jové M; Mota-Martorell N; Obis È; Sol J; Martín-Garí M; Ferrer I; Portero-Otín M; Pamplona R

    Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain.

    Antioxidants 12 -. .

    [doi:10.3390/antiox12010177]

  • Sol, J; Colàs-Campàs L; Mauri-Capdevila, G; Molina-Seguin, J; Galo-Licona, JD; Torres-Querol, C; Aymerich, N; Ois, A; Roquer, J; Tur, S; García-Carreira MDC; Marti-Fabregas, J; Cruz-Culebras, A; Segura, T; Pamplona, R; Portero-Otin, M; Arque, G; Jove, M; Purroy, F

    Ischemia preconditioning induces an adaptive response that defines a circulating metabolomic signature in ischemic stroke patients.

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 42 2201-2215. .

    [doi:10.1177/0271678X221116288]

  • del Castillo-Izquierdo, Angela; Moreno-Navarrete JM; Latorre, Jessica; Arnoriaga-Rodriguez, Maria; Ballanti, Marta; Monteleone, Giovanni; Alessandro Paoluzi O; Mingrone, Geltrude; Puig, Josep; Ramos, Rafael; Garre-Olmo, Josep; Jove, Mariona; Pamplona, Reinald; Portero-Otin, Manuel; Sol, Joaquim; Lefebvre, Philippe; Staels, Bart; Federici, Massimo; Fernández-Real JM; Mayneris-Perxachs, Jordi

    DPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection.

    Antioxidants 11 -. .

    [doi:10.3390/antiox11112177]

  • Pallarès J; Torreguitart N; Arqué G; Portero-Otin M; Purroy F

    Human atheromatous plaques expressed sensing adaptor STING, a potential role in vascular inflammation pathogenesis.

    THROMBOSIS AND HAEMOSTASIS 122 1621-1624. .

    [doi:10.1055/a-1772-1192]

  • Mayneris-Perxachs, J; Arnoriaga-Rodriguez, M; Garre-Olmo, J; Puig, J; Ramos, R; Trelis, M; Burokas, A; Coll, C; Zapata-Tona, C; Pedraza, S; Perez-Brocal, V; Ramio, L; Ricart, W; Moya, A; Jove, M; Sol, J; Portero-Otin, M; Pamplona, R; Maldonado, R; Fernandez-Real, JM

    Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function.

    ISME Journal 16 2181-2197. .

    [doi:10.1038/s41396-022-01262-3]

  • Torres, P; Anerillas, C; Ramirez-Nunez, O; Fernàndez A; Encinas, M; Povedano, M; Andres-Benito, P; Ferrer, I; Ayala, V; Pamplona, R; Portero-Otin, M

    The motor neuron disease mouse model hSOD1-G93A shows a non-canonical profile of senescence biomarkers.

    DISEASE MODELS & MECHANISMS 15 -. .

    [doi:10.1242/dmm.049059]

  • Parameswaran, J; Goicoechea, L; Planas-Serra, L; Pastor, A; Ruiz, M; Calingasan, NY; Guilera, C; Aso, E; Boada, J; Pamplona, R; Portero-Otin, M; de la Torre, R; Ferrer, I; Casasnovas, C; Pujol, A; Fourcade, S

    Activating cannabinoid receptor 2 preserves axonal health through GSK-3ß/NRF2 axis in adrenoleukodystrophy.

    ACTA NEUROPATHOLOGICA 144 241-258. .

    [doi:10.1007/s00401-022-02451-2]

  • Mayneris-Perxachs, J; Castells-Nobau, A; Arnoriaga-Rodriguez, M; Martin, M; de la Vega-Correa, L; Zapata, C; Burokas, A; Blasco, G; Coll, C; Escrichs, A; Biarnes, C; Moreno-Navarrete, JM; Puig, J; Garre-Olmo, J; Ramos, R; Pedraza, S; Brugada, R; Vilanova, JC; Serena, J; Gich, J; Ramio-Torrenta, L; Perez-Brocal, V; Moya, A; Pamplona, R; Sol, J; Jove, M; Ricart, W; Portero-Otin, M; Deco, G; Maldonado, R; Fernandez-Real, JM

    Microbiota alterations in proline metabolism impact depression.

    Cell Metabolism 34 681-70110. .

    [doi:10.1016/j.cmet.2022.04.001]

Projectes

  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Targeting cryptic exons as biomarkers and ALS therapy
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID
  • Metabolismo lipidico intracelular, procesamiento de ARNm y estrés celular en la encrucijada de la fisiopatología de la esclerosis lateral amiotrófica
  • Identification of compounds for inhibition of ACE2 membrane expression
  • Determinació de components bioactius derivats de la microbiota mitjançant micromostreig
  • Reposicionamiento terapéutico dirigido a inhibición de expresión de ACE2 y de proteolisis de trímero S viral
  • Estrés celulares y alteraciones en los lipidomas neuronales, gliales y extracelulares en la fisiopatología de la esclerosis lateral amiotrófica.
  • "Imagenoma de l'Envelliment": Estudi observacional poblacional per definir biomarcadors d'imatge RM corporal integral i òmics que s'associen al procés d'envelliment i a factors de risc biopsicosocial en subjectes adults i que defineixen la seva trajectòria vital cap a un envelliment saludable o bé la fragilitat i discapacitat.
  • Gut microbiota profile after consumption of a patented fiber formulation