Directori de persones
Manuel Portero Otin

Manuel Portero Otin

Grau: Doctor/a

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Grups

Publicacions

  • Serrano, JCE; Castro-Boque, E; Garcia-Carrasco, A; Moran-Valero, MI; Gonzalez-Hedstrom, D; Bermudez-Lopez, M; Valdivielso, JM; Espinel, AE; Portero-Otin, M

    Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial

    Nutrients 15 -. .

    [doi:10.3390/nu15173691]

  • Purroy, F; Ois, A; Jove, M; Arque, G; Sol, J; Mauri-Capdevila, G; Rodriguez-Campello, A; Pamplona, R; PORTERO, M; Roquer, J

    Lipidomic signature of stroke recurrence after transient ischemic attack

    SCIENTIFIC REPORTS 13 13706-13706. .

    [doi:10.1038/s41598-023-40838-7]

  • Torres P; Pamplona R; Portero-Otin M

    Cell senescence, loss of splicing, and lipid metabolism in TDP-43-related neurodegenerative processes.

    Neural Regeneration Research 18 1725-1726. .

    [doi:10.4103/1673-5374.363832]

  • Bernal AF; Mota N; Pamplona R; Area-Gomez E; Portero-Otin M

    Hakuna MAM-Tata: Investigating the role of mitochondrial-associated membranes in ALS.

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1869 166716-166716. .

    [doi:10.1016/j.bbadis.2023.166716]

  • Portero-Otin, M; de la Maza, MP; Uribarri, J

    Dietary Advanced Glycation End Products: Their Role in the Insulin Resistance of Aging

    Cells 12 -. .

    [doi:10.3390/cells12131684]

  • Sol J; Obis È; Mota-Martorell N; Pradas I; Galo-Licona JD; Martin-Garí M; Fernández-Bernal A; Ortega-Bravo M; Mayneris-Perxachs J; Borrás C; Viña J; de la Fuente M; Mate I; Biarnes C; Pedraza S; Vilanova JC; Brugada R; Ramos R; Serena J; Ramió-Torrentà L; Pineda V; Daunis-I-Estadella P; Thió-Henestrosa S; Barretina J; Garre-Olmo J; Portero-Otin M; Fernández-Real JM; Puig J; Jové M; Pamplona R

    Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.

    AGING CELL 22 -. .

    [doi:10.1111/acel.13821]

  • Planas-Serra L; Launay N; Goicoechea L; Heron B; Jou C; Juliá-Palacios N; Ruiz M; Fourcade S; Casasnovas C; De La Torre C; Gelot A; Marsal M; Loza-Alvarez P; García-Cazorla À; Fatemi A; Ferrer I; Portero-Otin M; Area-Gómez E; Pujol A

    Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity.

    JOURNAL OF CLINICAL INVESTIGATION 133 -. .

    [doi:10.1172/JCI162957]

  • Obis, E; Sol, J; Andres-Benito, P; Martin-Gari, M; Mota-Martorell, N; Galo-Licona, JD; Piñol-Ripoll G; Portero-Otin, M; Ferrer, I; Jove, M; Pamplona, R

    Lipidomic Alterations in the Cerebral Cortex and White Matter in Sporadic Alzheimer's Disease.

    Aging and Disease 14 1887-1916. .

    [doi:10.14336/AD.2023.0217]

  • Muñoz-Basagoiti J; Monteiro FLL; Krumpe LRH; Armario-Najera V; Shenoy SR; Perez-Zsolt D; Westgarth HJ; Villorbina G; Bomfim LM; Raïch-Regué D; Nogueras L; Henrich CJ; Gallemí M; Moreira FRR; Torres P; Wilson J; D'arc M; Marfil S; Herlinger AL; Pradenas E; Higa LM; Portero-Otin M; Trinité B; Twyman RM; Capell T; Tanuri A; Blanco J; Izquierdo-Useros N; Rech EL; Christou P; O'Keefe BR

    Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2.

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 120 -. .

    [doi:10.1073/pnas.2214561120]

  • Jové M; Mota-Martorell N; Obis È; Sol J; Martín-Garí M; Ferrer I; Portero-Otin M; Pamplona R

    Ether Lipid-Mediated Antioxidant Defense in Alzheimer's Disease.

    Antioxidants 12 -. .

    [doi:10.3390/antiox12020293]

  • Jové M; Mota-Martorell N; Obis È; Sol J; Martín-Garí M; Ferrer I; Portero-Otín M; Pamplona R

    Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain.

    Antioxidants 12 -. .

    [doi:10.3390/antiox12010177]

  • Sol, J; Colàs-Campàs L; Mauri-Capdevila, G; Molina-Seguin, J; Galo-Licona, JD; Torres-Querol, C; Aymerich, N; Ois, A; Roquer, J; Tur, S; García-Carreira MDC; Marti-Fabregas, J; Cruz-Culebras, A; Segura, T; Pamplona, R; Portero-Otin, M; Arque, G; Jove, M; Purroy, F

    Ischemia preconditioning induces an adaptive response that defines a circulating metabolomic signature in ischemic stroke patients.

    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 42 2201-2215. .

    [doi:10.1177/0271678X221116288]

Projectes

  • SEED-ALS: Synergizing Efforts to Develop and Accelerate Breakthroughs in ALS Research
  • Natural microbicides from rice against current and emerging infectious diseases
  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Targeting cryptic exons as biomarkers and ALS therapy
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • Comprehensive Roadmap and Preclinical Evaluation of Antisense Oligonucleotides (ASOs) Regulatory Development and Toxicological Assessment for ALS Treatment
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID
  • Metabolismo lipidico intracelular, procesamiento de ARNm y estrés celular en la encrucijada de la fisiopatología de la esclerosis lateral amiotrófica
  • Identification of compounds for inhibition of ACE2 membrane expression
  • Reposicionamiento terapéutico dirigido a inhibición de expresión de ACE2 y de proteolisis de trímero S viral
  • Determinació de components bioactius derivats de la microbiota mitjançant micromostreig