Manuel Portero Otin
Grau: Doctor/a
973 702 408
manuel.portero(ELIMINAR)@udl.cat
ResearcherID: http://www.researcherid.com/rid/B-7122-2009
Publicacions
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Sanchez-Roman, Ines; Gomez, Alexia; Gomez, Jose; Suarez, Henar; Sanchez, Carlota; Naudi, Alba; Ayala, Victoria; Portero-Otin, Manuel; Lopez-Torres, Monica; Pamplona, Reinald; Barja, Gustavo
Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES 43 699-708. .
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Galino, Jorge; Ruiz, Montserrat; Fourcade, Stephane; Schlueter, Agatha; Lopez-Erauskin, Jone; Guilera, Cristina; Jove, Mariona; Naudi, Alba; Garcia-Arumi, Elena; Andreu, Antoni L.; Starkov, Anatoly A.; Pamplona, Reinald; Ferrer, Isidre; Portero-Otin, Manuel; Pujol, Aurora
Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy.
ANTIOXIDANTS & REDOX SIGNALING 15 2095-2107. .
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Ayala, Victoria; Belen Granado-Serrano, Ana; Cacabelos, Daniel; Naudi, Alba; Ilieva, Ekaterina V.; Boada, Jordi; Caraballo-Miralles, Victor; Llado, Jeronia; Ferrer, Isidro; Pamplona, Reinald; Portero-Otin, Manuel
Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS.
ACTA NEUROPATHOLOGICA 122 259-270. .
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Jove, Mariona; Serrano, Jose C. E.; Ortega, Nadia; Ayala, Victoria; Angles, Neus; Reguant, Jordi; Morello, Jose R.; Paz Romero, Maria; Jose Motilva, Maria; Prat, Joan; Pamplona, Reinald; Portero-Otin, Manuel
Multicompartmental LC-Q-TOF-based metabonomics as an exploratory tool to identify novel pathways affected by polyphenol-rich diets in mice.
JOURNAL OF PROTEOME RESEARCH 10 3501-3512. .
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Lopez-Erauskin, Jone; Fourcade, Stephane; Galino, Jorge; Ruiz, Montserrat; Schlueter, Agatha; Naudi, Alba; Jove, Mariona; Portero-Otin, Manuel; Pamplona, Reinald; Ferrer, Isidre; Pujol, Aurora
Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy.
ANNALS OF NEUROLOGY 70 84-92. .
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Ochoa, Julio J.; Pamplona, Reinald; Carmen Ramirez-Tortosa, M.; Granados-Principal, Sergio; Perez-Lopez, Patricia; Naudi, Alba; Portero-Otin, Manuel; Lopez-Frias, Magdalena; Battino, Maurizio; Quiles, Jose L.
Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q10.
FREE RADICAL BIOLOGY AND MEDICINE 50 1053-1064. .
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Ilieva, Ekaterina V.; Kichev, Anton; Naudi, Alba; Ferrer, Isidre; Pamplona, Reinald; Portero-Otin, Manuel
Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 70 253-263. .
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Saborido, Ana; Naudi, Alba; Portero-Otin, Manuel; Pamplona, Reinald; Megias, Alicia
Stanozolol treatment decreases the mitochondrial ROS generation and oxidative stress induced by acute exercise in rat skeletal muscle.
Journal Of Applied Physiology (bethesda, Md. : 1985) 110 661-669. .
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Sanchez-Roman, Ines; Gomez, Jose; Naudi, Alba; Ayala, Victoria; Portero-Otin, Manuel; Lopez-Torres, Monica; Pamplona, Reinald; Barja, Gustavo
The ß-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.
REJUVENATION RESEARCH 13 683-693. .
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Negre-Salvayre, Anne; Auge, Nathalie; Ayala, Victoria; Basaga, Huveyda; Boada, Jordi; Brenke, Rainer; Chapple, Sarah; Cohen, Guy; Feher, Janos; Grune, Tilman; Lengyel, Gabriella; Mann, Giovanni E.; Pamplona, Reinald; Poli, Giuseppe; Portero-Otin, Manuel; Riahi, Yael; Salvayre, Robert; Sasson, Shlomo; Serrano, Jose; Shamni, Ofer; Siems, Werner; Siow, Richard C. M.; Wiswedel, Ingrid; Zarkovic, Kamelija; Zarkovic, Neven
Pathological aspects of lipid peroxidation.
FREE RADICAL RESEARCH 44 1125-1171. .
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Jacobson, Jake; Lambert, Adrian J.; Portero-Otin, Manuel; Pamplona, Reinald; Magwere, Tapiwanashe; Miwa, Satomi; Driege, Yasmine; Brand, Martin D.; Partridge, Linda
Biomarkers of aging in Drosophila.
AGING CELL 9 466-477. .
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Hiona, Asimina; Sanz, Alberto; Kujoth, Gregory C.; Pamplona, Reinald; Seo, Arnold Y.; Hofer, Tim; Someya, Shinichi; Miyakawa, Takuya; Nakayama, Chie; Samhan-Arias, Alejandro K.; Servais, Stephane; Barger, Jamie L.; Portero-Otin, Manuel; Tanokura, Masaru; Prolla, Tomas A.; Leeuwenburgh, Christiaan
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.
PLOS ONE 5 -. .
Projectes
- Natural microbicides from rice against current and emerging infectious diseases
- Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
- Targeting cryptic exons as biomarkers and ALS therapy
- Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
- The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
- Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID
- Metabolismo lipidico intracelular, procesamiento de ARNm y estrés celular en la encrucijada de la fisiopatología de la esclerosis lateral amiotrófica
- Identification of compounds for inhibition of ACE2 membrane expression
- Reposicionamiento terapéutico dirigido a inhibición de expresión de ACE2 y de proteolisis de trímero S viral
- Determinació de components bioactius derivats de la microbiota mitjançant micromostreig
- Estrés celulares y alteraciones en los lipidomas neuronales, gliales y extracelulares en la fisiopatología de la esclerosis lateral amiotrófica.
- "Imagenoma de l'Envelliment": Estudi observacional poblacional per definir biomarcadors d'imatge RM corporal integral i òmics que s'associen al procés d'envelliment i a factors de risc biopsicosocial en subjectes adults i que defineixen la seva trajectòria vital cap a un envelliment saludable o bé la fragilitat i discapacitat.
