Directory
Rosa Maria Soler Tatche

Rosa Maria Soler Tatche

Degree: PhD

973 702 264
rosa.soler(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/A-7361-2010

Groups

Publications

  • Gou-Fabregas, Myriam; Garcera, Ana; Mincheva, Stefka; Jose Perez-Garcia, M.; Comella, Joan X.; Soler, Rosa M.

    Specific vulnerability of mouse spinal cord motoneurons to membrane depolarization.

    JOURNAL OF NEUROCHEMISTRY 110 1842-1854. .

    [doi:10.1111/j.1471-4159.2009.06278.x]

  • Perez-Garcia, M. Jose; Gou-Fabregas, Myriam; de Pablo, Yolanda; Llovera, Marta; Comella, Joan X.; Soler, Rosa M.

    Neuroprotection by neurotrophic factors and membrane depolarization is regulated by calmodulin kinase IV.

    Journal Of Biological Chemistry 283 4133-4144. .

    [doi:10.1074/jbc.M705477200]

  • de Pablo, Yolanda; Perez-Garcia, M. Jose; Georgieva, Maya V.; Sanchis, Daniel; Lindqvist, Niclas; Soler, Rosa M.; Comellal, Joan X.; Lloveral, Marta

    Tyr-701 is a new regulatory site for neurotrophin receptor TrkA trafficking and function.

    JOURNAL OF NEUROCHEMISTRY 104 124-139. .

    [doi:10.1111/j.1471-4159.2007.05027.x]

  • Fernandez-Gomez, F. J.; Pastor, M. D.; Garcia-Martinez, E. M.; de Mera, R. Melero-Fernandez; Gou-Fabregas, M.; Gomez-Lazaro, M.; Calvo, S.; Soler, R. M.; Galindo, M. F.; Jordan, J.

    Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression.

    NEUROBIOLOGY OF DISEASE 24 296-307. .

    [doi:10.1016/j.nbd.2006.07.005]

  • Perez-Garcia, MJ; Cena, V; de Pablo, Y; Llovera, M; Comella, JX; Soler, RM

    Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway.

    Journal Of Biological Chemistry 279 6132-6142. .

    [doi:10.1074/jbc.M308367200]

  • Dolcet, X; Soler, RM; Gould, TW; Egea, J; Oppenheim, RW; Comella, JX

    Cytokines promote motoneuron survival through the Janus kinase-dependent activation of the phosphatidylinositol 3-kinase pathway.

    MOLECULAR AND CELLULAR NEUROSCIENCE 18 619-631. .

    [doi:10.1006/mcne.2001.1058]

  • Egea, J; Espinet, C; Soler, RM; Dolcet, X; Yuste, VJ; Encinas, M; Iglesias, M; Rocamora, N; Comella, JX

    Neuronal survival induced by neurotrophins requires calmodulin.

    JOURNAL OF CELL BIOLOGY 154 585-597. .

    [doi:10.1083/jcb.200101023]

  • Comella, J; Egea, J; Soler, RM; Dolcet, X; Espinet, C

    Ca2+ and calmodulin regulate neuronal survival throughout the modulation of the intracellular signaling pathways activated by receptors for neurotrophic factors

    METHOD FIND EXP CLIN 22 395-396. .

  • Egea, J; Espinet, C; Soler, RM; Peiro, S; Rocamora, N; Comella, JX

    Nerve growth factor activation of the extracellular signal-regulated kinase pathway is modulated by Ca2+ and calmodulin

    MOLECULAR AND CELLULAR BIOLOGY 20 1931-1946. .

    [doi:10.1128/MCB.20.6.1931-1946.2000]

  • Soler, RM; Dolcet, X; Encinas, M; Egea, J; Bayascas, JR; Comella, JX

    Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons.

    JOURNAL OF NEUROSCIENCE 19 9160-9169. .

  • Dolcet, X; Egea, J; Soler, RM; Martin-Zanca, D; Comella, JX

    Activation of phosphatidylinositol 3-kinase, but not extracellular-regulated kinases, is necessary to mediate brain-derived neurotrophic factor-induced motoneuron survival.

    JOURNAL OF NEUROCHEMISTRY 73 521-531. .

    [doi:10.1046/j.1471-4159.1999.0730521.x]

  • Becker, E; Soler, RM; Yuste, VJ; Gine, E; Sanz-Rodriguez, C; Egea, J; Martin-Zanca, D; Comella, JX

    Development of survival responsiveness to brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5, but not to nerve growth factor, in cultured motoneurons from chick embryo spinal cord.

    JOURNAL OF NEUROSCIENCE 18 7903-7911. .

Projects

  • FI-SDUR
  • Identificación de nuevas dianas para el desarrollo de terapias combinadas en la Atrofia Muscular Espinal
  • Preclinical Analisis of new combinatorial treatments for spinal muscular atrophy (SMA): Effects on motorneuron survival, synaptic integrity, and skeletal muscle preservation.
  • Analysis of the beneficial effects of calpain inhibitors treatment and combined therapies on Spinal Muscular Atrophy
  • Nuevas terapias para el tratamiento de la Atrofia Muscular Espinal: inhibidores de la calpaina y células madre mesenquimales modificadas
  • Desarrollo de nuevas estrategias terapéuticas para el tratamiento de la atrofia muscular espinal: regulación de la autofagia y las vías de señalización intracelular
  • Estudio degeneración de lasl motoneuronas en un model celular de atrofia muscular espinal
  • ESTUDIO SOBRE LA INTEGRACION DE LAS VIAS DE SEÑALIZACION INTRACELULAR RESPONSABLES DE LA SUPERVIVENCIA DE LAS MOTONEURONAS ESPINALES Y SU IMPLICACION EN LAS ENFERMEDADES NEURODEGENERATIVAS
  • Papel funcional del estrés oxidativo y nitrosativo en grandes sistemas biológicos.